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In addition to pederin, its derivatives pseudo-pederin, pederon, etc. have biological activity. Pederin is able to block protein synthesis in the cytoplasm of eukaryotes. When pederin enters the digestive tract, enteritis is observed. The kidneys are affected to a lesser extent than with cantharidin poisoning. Ecology and biology. Small beetles 9-12 mm long. The body is colored from dirty yellow to order albenza online. Head with black spots. Elytra with black stripes. Common on nightshades. Dangerous potato pest.

In a house fly, when 1 μl of beetle hemolymph is injected, death occurs within 1 hour. Administration of lyophilized hemolymph to mice at a dose of 25 mg/kg causes contracture of the abdominal muscles at the injection site, adynamia, and difficulty breathing. Before death, convulsions, rotational movements develop. The heart stops in diastole. In rats, a progressive decrease in body temperature is observed until the moment of death. The hematocrit increases by 45-70%, the urea content in the blood serum increases by 2 times, and the activity of aspartate aminotransferase and lactate dehydrogenase increases significantly. The electrolyte balance of plasma is disturbed in the direction of hyperkalemia and hypercalcemia.

55,000, named β-leptinotarzine. The hemolymph of the closely related species Leptinotarsa haldemani contains a toxin called β-leptinotoxin-h. Leptinotarzin is not accumulated with food, but is a natural protein of the beetle hemolymph. The toxin is quite resistant to the action of proteolytic enzymes, however, incubation with the body homogenate of albendazole beetle completely inactivates it. Apparently, the body of the beetle has a detoxifying system. Leptinotarzine has an effect on neuromuscular transmission in vertebrates. At concentrations of 10 -11 - 10 -10 mol/l, leptinotoxin-h enhances Ca 2+ entry into rat brain synaptosomes, and is also capable of releasing mediators from preloaded synaptosomes. This effect is also observed incalcium environment, but calcium accelerates it.

Hemolymph is poisonous to invertebrates and vertebrates. Chemical composition and mechanism of action of albenza pills. The active principle of the poison is a protein with M r. Under the action of leptinotoxin-h, fusion of vesicles and the formation of large membrane folds are observed in synaptosomes. In neurosecretory cells, a decrease in the number of secretory granules was noted. Apparently, the toxin stimulates the process of exocytosis. The hemolymph of the Colorado potato beetle is low toxic (DL 50.

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On the other hand, adults and larva have aposematic coloration, which warns the predator about possible inedibility. The biological role of leptinotarzine remains to be elucidated. In any case, the combination of poisonous hemolymph with the presence of enzyme systems that effectively detoxify xenobiotics, including insecticides, largely explains its wide distribution. Under the pressure of the resulting gases, the mixture is fired in the form of an aerosol at a temperature of -100°C. Gourd ladybug Epilachna chrysomelina.

Many beetles defend themselves by spraying caustic or toxic substances. For example, dark beetles and ground beetles secrete benzoquinones and toluquinones. Dytiscus swimming beetles secrete a milky fluid containing 11-deoxycorticosterone, a precursor of aldosterone in vertebrates. Under its influence, fish develop a violation of water-salt metabolism and osmotic balance up to a state of shock. Description and photo of blister beetles.

Bug beetles (lat. Meloidae) live all over the world, prefer countries with a warm climate. Insects of medium size, bright color, with an elongated body, lowered head. The name was given due to the presence of a special substance - cantharidin, which causes abscesses on the skin of humans and mammals. In total there are about 7500 species.